Do Brine Shrimp Diagnose Cystic Fibrosis?

Cystic Fibrosis: How do CFTR mutations cause cystic fibrosis?

Two major discoveries have transformed our understanding of cystic fibrosis, a genetic disease in which thick secretions accumulate in airways, digestive organs and sperm duct. The first was that cystic fibrosis involves a basic defect in epithelial ion transport [1], which is manifested primarily as the loss of chloride conductance [2]. The connection between the loss of epithelial chloride co...

Sweat tests to diagnose cystic fibrosis in adults.

Twenty five patients with cystic fibrosis and 25 controls were studied to define a sweat sodium concentration in adults that could be taken as diagnostic of cystic fibrosis. Some of the controls had a sweat sodium concentration of over 50 mmol(mEq)/l, and thus cystic fibrosis should be diagnosed in an adult only when two measurements of sweat sodium concentration are above 70 mmol/l. In cases i...

Nucleotide metabolism during brine shrimp embryogenesis.

Changes in the amounts of acid-soluble nucleotides during embryonic development of the encysted egg of the brine shrimp, Artemia salina, have been determined. Significant quantities of diguanosine tetraphosphate, the most abundant compound in the nucleotide pool, are apparently not utilized until hatching, at which time the amount falls precipitously. Diguanosine triphosphate, a homologue of th...

Maintaining Respiratory Health in Cystic Fibrosis Patients

Cystic fibrosis (CF) is an inherited disease that primarily affects the lungs and the digestive system, however, it also affects a number of other organs and systems. More than 90% of mortality of  CF patients is due to lung complications.  Healthy lungs are important for a long life for people with CF, We will discuss two important topics for maintaining respiratory health. Chronic use of drug...

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